Martin Breuss undertook a diploma thesis in the lab of Vic Small on cytoskeletal dynamics in cell migration. Martin joined the Keays lab in 2009 and worked on the role of tubulin genes in neurodevelopment and disease. He showed that mutations in the tubulin isoform TUBB5 cause microcephaly with structural brain abnormalities. See Breuss et al, Cell Reports, 2012. Martin was the first PhD student to graduate from the Keays lab. He currently holds an EMBO Fellowship and is undertaking his post-doctoral work with Dr Joesph Gleeson at UCSD.
Thomas Gstrein performed his undergraduate studies at the University of Innsbruck in biological sciences before joining the Masters program in molecular biology at the University of Vienna. He undertook his PhD in the Keays lab focusing on the molecular mechanisms that facilitate neuronal migration. Thomas showed that a hypomorphic mutation in Vps15 caused a hippocampal migration defect in the Marble mouse. He further demonstrated that this mutation perturbs endosomal-lysosomal trafficking and autophagy, resulting in an upregulation of Nischarin, which inhibits Pak1 signaling (Gstrein et al, Nature Neuroscience 2018). Thomas now works for Teva Pharmaceuticals as a consultant, and he still can’t beat Dave at squash.
Mattias Lauwers joined the Keays lab in 2011 as a PhD student. Mattias was responsible for discovering the “cuticulosome” in Avian hair cells (Lauwers et al, Current Biology, 2013). Mattias was a brilliant experimentalist, a patient and thoughtful scientist, a lover of all things made of cheese, and a wonderful friend. He died following a mountain biking accident on September 12th 2014. There are no words to describe how much we miss him.
Jasmin Morandell joined the Keays lab in 2013 as a Masters student. Jasmin’s thesis focused on Tubb2b, a gene that has been implicated in a variety of brain disorders. Jasmin showed that Tubb2b undergoes a developmental transition in cortical neurons. Tubb2b is abundantly expressed in both progenitors and post-mitotic neurons in development, but is restricted to the glial lineage in adulthood (See Breuss and Morandell, Journal of Comparative Neurology 2015). Jasmin is currently undertaking a doctorate at the Austrian Institute of Technology.
Christoph Treiber was the first student to join the Keays lab in 2008. As a diploma student he showed that clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons. Christoph is currently undertaking a doctorate at Oxford University with Professor Scott Waddel. See Treiber et al, Nature, 2012.
Andreas Braun joined the Keays lab in 2009 as a diploma student. Andreas profiled the expression of tubulin genes during neurodevelopment. He showed that Tuba8 is expressed at very low levels in the developing brain, whereas Tubb5 is enriched in stem cells and post-mitotic neurons. Andreas completed his doctorate at the Centre for Gene Regulation in Barcelona, before pursing a career in management consulting. See Braun et al, AJHG, 2010.
Lorenz Fenk joined the Keays lab in 2009 as a bachelor student. Lorenz investigated whether C57/Bl6 mice can be conditioned to magnetic stimuli. He undertook a doctoral project at the University of Cambridge under the supervision of Dr Mario de Bono, and is currently a post-doc with Dr Gilles Laurent at the Max Plank Institute for Brain Research.
Paul Pichler joined the Keays lab in 2010 as a diploma student. Paul established a screen for magnetosensitive nematodes, and undertook ultrastructural analysis of the cuticulosome. Paul is currently a doctoral student at the University of Sussex working with Dr Leon Lagnado. See Lauwers and Pichler et al, 2013.
Marion Salzer joined the Keays lab in 2009 as a bachelor student. Working alongside Christoph Trieber, Marion employed histological techniques to show that a conserved magnetic sense system in the upper beak of pigeons does not exist. She is currently undertaking a doctoral project at the Institute for Research in Biomedicine in Barcelona.
Nathaniel Edelman joined the Keays lab in 2011 as a research technician. Nate pioneered the development of single cell correlative light and electron microscope permitting the analysis of putative magnetoreceptors in pigeons and trout. In 2014 he was accepted into a doctoral program at Harvard University and will work with Professor Jim Mallet on butterfly speciation.
Kelvin Chan joined the Keays lab in 2013 as a Fullbright Scholar. Kelvin joined forces with Martin Breuss and investigated the effect of Tubb5 mutations on the progression of the cell cycle. He is currently attending medical school as part of the NIH Medical Scientist Training Program (MD/PhD) at Stony Brook University and the Cold Spring Harbour Laboratories.
Andi Hansen initially joined the Keays lab as a bachelors student where he focused on the behavioural characterisation of a number of mouse mutants. As a Masters student Andi turned his attention to the multi-tubulin hypothesis, establishing a live cell imaging set up to assess microtubule dynamics. Andi is currently a doctoral student at the Austrian Institute of Technology. Andi likes Bonferroni corrections.
Tanja Fritz graduated from the University of Applied Sciences in Krems and then undertook her Masters thesis in the Keays lab in 2012. Employing the “magnetoscope” she screened for magnetic cells in the pigeon and the rainbow trout. After a stint as a part time technician in the Keays lab, she started medical studies at the Medical University of Vienna.
Artemis Papadaki-Anastasopoulou studied Molecular Biology and Genetics at the Democritus University of Thrace in Greece. She followed this with a Masters degree in Neuroscience at the University of Edinburgh where she worked on seasonal expression of hormone receptors in a free-living arctic bird. Artemis joined the Keays lab in October 2014 where her work focused on understanding the neural basis of magnetoreception. She is currently undertaking a Masters degree in science communication at the University of Vienna, and dating a strapping young Philosopher.
William Snider received his Bachelor’s degree in Biochemistry from Columbia University. As an undergraduate, he worked in the labs of Rafael Yuste and René Hen, studying interneuron microcircuits and the function of the raphe nuclei in adaptive emotional responses (see Karnani et al, Neuron 2016). William initially joined the Keays lab as a VBC summer student in 2016, and returned as a research assistant in February 2017. In October 2018 he started a PhD in neuroscience at Johns Hopkins University. Tobias taught William how to perform laser dissection microscopy, and Dave taught him how to play poker.